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A two-level full factorial design was employed for the screening of the variables and a four-variables Doehlert design was applied for full optimization of the procedure.
The method was optimized regarding its instrumental conditions through a multivariate strategy based on the screening of the variables, to identify the significant ones, followed the application of a response surface methodology.
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Covariates of concern were identified from the literature, the conceptual model we developed a priori, and an empirical screen of the variables available.
Screening of the appropriate variables and optimization of the lipase production was performed using Plackett-Burman design (PBD) and response surface methodology (RS M.
The statistical methods of screening the variables also differed between studies.
The impact of the offer of screening is the variable of primary interest for health policy decisions on implementation of screening offers, whereas the effect of actual use of screening (compared with non-use) is the parameter of primary interest for individual patient consulting and patient decisions.
Table 3 represents the results of the screening of significant variables for L-asparaginase production and the corresponding response (Y) using Plackett-Burman design.
First of all, due to the complexity of large sport buildings, the formulation of the optimization and the screening of the related design variables is crucial in order to obtain a meaningful design space, which helps reducing unnecessary computational burden.
In the screening of the air pollution variables, non-freeway NOx levels were significantly and positively associated with BMI at age 10 and the rate of growth over the four year follow-up period, while the freeway-related exposures were not associated with BMI growth, consistent with other previous studies on respiratory health [ 27].
The design matrix for the screening of significant variables for enzyme production and the corresponding responses are shown in Table 2.
The paper discusses the screening of experimental variables leading to formation of a columnar microstructure in suspension plasma sprayed zirconia coatings.
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