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Rapid screening of libraries of catalysts provided a basic understanding of catalyst structure (sterics, electronics, etc).
Two recently published books examine combinatorial materials synthesis, high-throughput screening of libraries, and the design of successful experiments.
Here we describe a facile, inexpensive, and robust method for the screening of libraries of mutated enzymes with iodoalkane substrates.
Large scale screening of libraries consisting of natural and small molecules led to the identification of many small molecule inhibitors repressing Wnt/β-Catenin signaling.
Through design, synthesis and semi-HTP screening of libraries of novel benzimidazoles, followed by SAR studies, we identified highly potent lead compounds.
In this article, the application of NMR to the screening of libraries of small, so-called "fragment" compounds that can be used as starting-points for development of novel medicines is discussed.
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In theory, we should have been able to identify LXY30 from the screening of library L1, but we failed to pick it up.
To establish a transketolase-inhibitory anticancer therapy, a high throughput screening of library compounds using recombinant human transketolase (TKT) has been performed.
However, discovery of such combinations requires screening of large libraries of chemicals and the size of such libraries increases exponentially with the number of ingredients in the formulation.
The methodology consists of iterative design, synthesis, and X-ray crystallographic screening of three libraries of compounds.
This assay is appropriate for high-throughput screening of ligand libraries.
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