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Therefore, our method is a good solution for automatic screening of DNA data, especially for large DNA sequencing facilities.
It means we can use SVM for automatic quality screening of DNA chromatograms.
Screening of DNA polymorphisms in the Gn1a gene using WGS data.
We devised a new method to fulfill the quality screening of DNA chromatograms.
Here, we developed a sensitive electrochemical method for assay of DNA methyltransferase (MTase) activity and screening of DNA MTase inhibitor without labeling processes.
This electrochemical method had the potential application in the screening of DNA MTase inhibitor, provided valuable information for anti-cancer drug research and also for cancer therapy.
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Through screening of DNA-encoded peptide libraries against KDM1 and -4 histone demethylases by phage display, two cyclic peptides targeting the histone demethylase KDM4C were identified and developed as inhibitors by amino acid replacement, truncation, and chemical modifications.
The identification of such genes represents a significant technical challenge, although technologies for the genome-wide screening of DNA-methylation patterns and histone marks that would be required for target gene identification are starting to become available (see below).
Lau et al. applied a genome-wide screen of DNA methylation changes using NB primary tumors [ 26].
We previously reported a genome-wide screen of DNA methylation differences among T2D cases and controls in the Ashkenazi Jew (AsJ) population.
If a limited range of mutations are normally positively selected by therapy, then these might be detectable, before therapy, by sensitive screens of DNA fragments in plasma (Murtaza et al, 2013).
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