Sentence examples for screening of a kinase from inspiring English sources

This unique fluorescent probe was successfully applied to the screening of a kinase focused compound library.

PI3K and mTOR inhibitors were revealed by screening of a kinase inhibitor chemical library to positively combine with both DDR1-IN-1 and DDR1-IN-2.

The primary screening of a kinase inhibitor (KI) library comprised of 244 KIs was purchased from EMD Chemicals, and diluted with DMSO to 2 mM concentrations for high-throughput screening purposes.

In this work, we have demonstrated the potential to use WAC in combination with mass spectrometry (MS) detection for fragment screening of a kinase target cyclin G-associated kinase (GAK).

Cell-based screening of a preselected kinase-based small molecule compound library identified A-770041 as one of the most effective drug resistance reversing agents in two osteosarcoma MDR cell line models, U-2OSMR and KHOSR2, having defined overexpression of the major MDR transporters, ABCB1/Pgp.

Herein we report a screen of a focused kinase library against T. brucei GSK3.

This work involved a high-throughput screen of a focussed kinase set of ∼3400 compounds to identify potent and parasite-selective inhibitors of an enzymatic Leishmania CRK3 cyclin 6 complex.

In summary, we have shown that a screen of a focused kinase library led to the identification of ligand-efficient inhibitors of TbGSK3 with sub-micromolar potency.

A road map of phenotypic screen of a mammalian kinase inhibitor -> target ID by chemical proteomics in gel -> chemical proteomics using ITRAQ -> RNAi screen of candidate targets -> target engagement studies -> reconfirmation with recombinant enzymes, possibly as a figure, would help.

A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed >50%% inhibition at 5 μ m.

Finally, compounds must be able to penetrate cells and have a sufficient free fraction in the assay to elicit their response, eliminating compounds with inappropriate properties.[ 12– 14] We therefore decided to conduct a phenotypic screen of a focused kinase compound library against whole parasites.