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Until such data are available, the possibility will exist that metabolic variants of major effect, suitable for predictive diagnostic screening in the same way as target site variants, are masked by low LD and remain undetected.
To characterize the genomic organization of the O. nubilalis OR genes, we isolated BAC clones containing OR genes from an O. nubilalis BAC library by PCR-based screening in the same manner as described previously [27].
We randomly sampled 1410 referents from the population invited for screening in the same period.
A second screening in the same population was carried out in 2005, comprising now 2216 individuals.
Next to the screening through VIA, we performed conventional cytological screening in the same setting.
Our serial screening in the same population indicated that seropositivity and the disease may also appear later in life.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com