Multi-scale understanding is fostered by adaptive management, which uses fine-scale, mechanistic understanding to screen hypotheses to be tested at large-scales.
To screen hypotheses in an exploratory analysis of which factors influence correct treatment for pneumonia, we used logistic regression modelling to examine 44 factors for their association with treatment quality.
Computational approaches have made key contributions to perform efficient analyses of data, filtering compounds collections to select molecules for experimental screening, generate hypothesis to understand the mechanism of action of drugs, and the design of new chemical structures.
It is noteworthy that, in our initial virus gene amplification screening, a hypothesis for PCR primer design, based on an early report that EEEV causes egg-drop in turkey [12], helped us have obtained BYDV gene fragments.
Before considering the model for virtual screening, the hypothesis was overlayed on the enzyme active site and then visually analyzed.
Since replication screens are hypothesis-driven, they avoid the stringent multiple test correction penalties of a GWAS/WGS (p < 10-8).
In fact, we screened this hypothesis in a subgroup of participants (5 HC, 7 MCI and 3 AD patientsb) which were asked to rate the images after the post-scan test as emotional or non-emotional.
In order to select the best-performing model for the virtual screening campaign, the hypotheses were validated thoroughly.
This chapter explains the methodology for designing and analyzing industrial experiments when selection and screening, rather than hypothesis testing, are the goals.
If one is willing to assume that the mother's age of death is exogenous to the individual mammography screening decision, the hypothesis that all other instruments are valid cannot be rejected.
