Sentence examples for screening hit from inspiring English sources

Based on a high throughput screening hit, pyrrolopyrimidine inhibitors of the Akt kinase are explored.

Starting from a screening hit, two new JAK2 inhibitor chemotypes were designed by scaffold morphing.

Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D.

A series of pyrimidones has been designed from a screening hit, and nanomolar inhibitors identified.

An orally active GPR4 antagonist 39c was developed, starting from a high throughput screening hit 1.

Herein, we establish structure activity relationships of 51 N-phenylphthalimide analogs of the screening hit 1.

Application of structure-based design to screening hit 1 yielded sub-micromolar inhibitors.

A screening hit 1 against Trypanosoma brucei methionyl-tRNA synthetase was optimized using a structure-guided approach.

Based on screening hit 1, a series of tricyclic quinoxalinones have been designed and evaluated for inhibition of PARP-1.

Beginning with a diaminotriazine screening hit, several series of novel, tricyclic gamma-secretase modulators (GSMs) were designed.

Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.