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Importantly, mere screening for reactivation might be insufficient as the ultimate goal is to kill the reactivated cells.
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Compounds were screened for reactivation of cyclosarin-, sandn- and VX-inhibited AChE and BChE.
Those with a positive viral load should receive prophylaxis while those with a negative PCR should be screened for reactivation on a regular basis [ 45] (AIII).
Screening for CMV or EBV reactivation by quantitative PCR is standard practice in bone marrow transplant patients.
Due to reports of hepatitis B reactivation, screening for hepatitis B and C should be considered in the appropriate clinical setting.
The incidence of these complications has been reduced by prophylaxis against Pneumocystis carinii pneumonia, preemptive therapy in patients at high risk for cytomegalovirus (CMV) reactivation, and, more recently, screening for serum CMV antigen.
Due to reports of hepatitis B reactivation after starting etanercept, screening for hepatitis B infection should be performed in the appropriate clinical setting.
As biologic agents can increase the risk of infections such as tuberculosis and reactivation of viral hepatitis, screening for the presence of latent tuberculosis and chronic viral hepatitis carrier state is recommended before initiating therapy.
The main measures consist of screening for markers indicating chronic HBV infection (HBsAg) or HBV infection in the distant past (antibodies to the HBV core antigen) before initiating biological therapies, vaccinating marker-negative patients, and considering close follow-up or antiviral treatment before immunosuppressive treatment initiation or in the event of HBV reactivation.
Screening for illegal substances.
The FoR defines the VZV-CMI needed to resist clinical reactivation and if VZV-CMI < FoR, reactivation will lead to HZ.
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