Exact(4)
We are screening for, discovering, and treating disease more frequently; people are living longer; and a greater proportion of the population is entering Medicare age – all leading to increasingly complex patients.
In this section, we examine the current trends in microbial product screening for discovering novel antibiotics.
The singling out of these mutants further validates our screening for discovering novel potential regulators of the CWI pathway.
The hit rate of our virtual screening is 36% (9/25), which is much higher than the hit rate (0.1%) of a cell-based high throughput screening for discovering KCNQ2 activators (http://pubchem.ncbi.nlm.nih.gov).nih.gov
Similar(56)
Due to its high sensitivity and specificity, it represents an ideal screening tool for discovering new potential producers of cyathane type diterpenoids.
In summary, we have developed a novel NMR screening method for discovering inhibitors against a specific target in cells where a diffusible substrate or product can be monitored.
Due to its high sensitivity and specificity, it represents an ideal screening method for discovering new cyathane diterpenoids and new potential producers of them.
By characterizing the complicated interactions between multiple components and multiple receptors, the proposed CMC analysis system can be applied as a preliminary screening tool for discovering active leading components from HMs or other complex medicine systems.
In the first one, von Mering et al. [ 49] combined the PPI data from the previous studies by Ito et al. [ 42] and Uetz et al. [ 44], with the aim of using the combined interaction dataset as a reference network when comparing different Y2H screening approaches for discovering physical protein interactions in yeast (VonMering).
Since genome-wide RNAi screens used for discovering functional genes in stem-cell self-renewal and pluripotency maintenance produce candidate lists that are inherently noisy, the SVM-based classifier can be applied to prioritize experimental choices when facing with a large list of candidate genes to verify and further functionally characterize.
NS-018 was discovered by screening for potent and selective JAK2 inhibitors.
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