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Structure-based virtual screening focused on potential allosteric surface cavities revealed these compounds [1].
New kinase inhibitors can be found by synthesis of targeted arrays of compounds designed using system-based knowledge as well as through screening focused or diverse compounds.
Here we describe our methodology of multi-step mAb screening focused on identifying mAbs exhibiting efficacy and specificity in labeling mammalian brain samples.
The clones showing activity halos were selected and transferred from 96-well plates to 96 deep-well microplates for the secondary screening, focused on the detection of variants with higher activity than the wild type enzyme in solution towards the chromogenic substrate AZO-CMC.
The clones showing activity halos were selected and transferred from 96-well plates to 96 deep-well microplates (Additional file 1: Fig. S1c, re-arraying) for the secondary screening, focused on the detection of variants with higher activity than the wild type enzyme in solution towards the chromogenic substrate AZO-CMC.
Targeted screening focused on presentations linked to mental health, gastrointestinal problems, hypertension, minor injuries, and new patient registrations.
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The screening focuses on off- and on-shore individual aquifers, gas and oil fields.
On the basis of the Survey of Health, Ageing, and Retirement (SHARE), we analyse the determinants of who engages in mammography screening focusing on European women aged 50-69 years. 50-69 years
The purpose of this paper was to conduct an empirical test of certain hypotheses implied by economic theory concerning the determinants of mammography screening focusing on European women aged 50-69 years using the SHARE data-base.
The first step is a historical account of population screening, focussing on the ways in which emerging practices of (genetic) screening have been mediated by an evolving moral landscape in our society.
Biomarker-based screening focuses on specific transcriptional activities to identify compounds of interest.
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