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(iii) A mode transition from local to propagating domain switching occurs when the screening below a critical value.
Only once further information on the effectiveness of screening below 50 years is available, can the cost-effectiveness of any change in policy can be estimated.
It appears likely that there will be a benefit in terms of reduced mortality from breast cancer associated with screening below 50 years, and that frequent (e.g. probably annual) screening will be necessary to achieve this.
For example, by checking the phenotypes of transcription regulator mutants from BUS, a limited characterized transcription factor rca-1 (NCU01312) [ 32] was found to affect the expression and production of cellulase and xylanase (see mutant screening, below).
In the UK, the effectiveness of screening below age 50 was identified as one of the areas where further research was needed, at the time the national screening programme was introduced (Forrest, 1986).
Until more information is available, it is difficult to inform either policy makers (in terms of potential changes to national screening programmes) or individual women on the balance between costs and effectiveness of screening below 50 years.
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