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Allosteric ribozymes have applications in molecular computing, biosensoring, high-throughput screening arrays, exogenous control of gene expression, and others.
A new optical detector system for fluorescence analysis in on-chip high-speed screening arrays is described.
The copy numbers for 138 BAC clones were compared between the screening arrays and the mini-arrays.
In screening arrays of known miRNAS for those that are differentially expressed by quiescent versus senescent cells (C.
We performed multiplex screening arrays to detect the soluble factors present in GC-MSCs CM that might be responsible for neutrophil activation.
The marker density on the screening arrays was one variant per ~ 1.7 kb on average over all chromosomes (Additional file 1: Table S3).
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To investigate this further a cytokine screening array was used (data not shown).
Thus, the use of this comprehensive screening array could potentially have a lower sensitivity and specificity in our patient population.
Although the density of the dots was less in the mini-array than in the screening 1.4 K arrays, the data by the mini-array analysis were virtually equivalent to those by the screening array (Fig 1c).
The 96 proprietary samples were included in the analysis of the screening array for training of the variant clustering algorithm, but not in further analyses presented here.
Ultimately, SNPs need to be validated by genotyping in a variety of reference mapping families and trait-selected populations using a high-density screening array.
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