E pl) is the sum of the proportion of localised disease detected by screening and the proportion of localised disease among interval cases where pls proportion of localised disease detected by screening; and plc proportion of localised disease detected clinically.
The authors also provide sensitivity analysis on the efficacy of fever screening equipment and proportion of cases with known exposure history who report correctly.
Whether ACF activities are cost-effective is context specific, but this analysis demonstrates that ACF programs can be cost-effective across a wide range of program costs, numbers of patients screened, and proportions identified as TB cases.
However, we have estimated the proportion of the population to be offered screening and the proportion of cancer cases that might be screen detectable in this subgroup of the population, from the distribution of genetic risk in the population.
We have used data from England to estimate the proportion of men 45 79 years that would be eligible for screening and the proportion of cases potentially detectable within the eligible population at different risk thresholds.
The proportion of men 45 79 years that would be eligible for screening and the proportion of cases potentially detectable within the eligible population at different risk thresholds are given in Figure 2. The eligible population for the personalised approach based on a 1.4% 10-year risk threshold would be the same size as the age 55 and over population.
To determine the proportion and features of invasive interval cancers that could be detected at the time of screening and the proportion classified as true-intervals, false-negatives, minimal signs or radiographically occult lesions.
Transition rates – that is, for incidence, growth, symptomatic disease – had Exp 0.01) prior distributions to ensure identifiability, whereas all other parameters – that is, for attendance at screening and initial proportions in each state – had uniform prior distributions over the parameter support (see Supplementary Material).
We will analyse the proportions of patients meeting the inclusion criteria; the proportion refusing to be screened; and the proportion of patients who screen positive.
DOI: http://dx.doi.org/10.7554/eLife.05564.005 10.7554/eLiFigure64.006 Figure 3 figure supplement 1. Expected proportions detected by screening when efficacy of fever screening is 50% and proportion of cases with known exposure history who report correctly is 0.25.
We investigated the proportion of individuals willing to be screened, and the proportion willing to accept a preventive intervention in those at risk.
