The screen that exhibited the highest criterion validity was the demographically adjusted HDS [ 40].
Among the eleven compounds confirmed in our secondary screen that exhibit strong synergy with PARPi in killing breast cancers irrespective of their BRCA1 status, four can inhibit NF-κB activity (lestaurtinib, bortezomib, ouabain, and digitoxin).
Therefore, incident carcinomas constitute a type of screen-detected carcinoma that exhibits a worse prognosis than prevalent carcinomas.
BUR1 and BUR2 were initially identified in a screen for mutants that exhibited increased transcription of the SUC2 gene in the absence of its upstream activating sequence (UAS) [61].
Recently, in an effort to systematically identify proteins that can mediate oxygen regulation and signaling, we performed a genome-wide screen for proteins that exhibit altered cellular distribution patterns in response to hypoxia and reoxygenation [ 11].
Bax, a proapoptotic member of the Bcl-2 family of proteins, was first discovered in a screen of proteins that exhibited binding interactions with Bcl-2 (Oltvai et al, 1993).
In parallel, we employed Polyphen2 analysis21 to identify genes that contain amino acid substitutions that are predicted to cause a significant alteration in function and screened for genes that exhibited evidence for positive selection.
We screened genomic regions that exhibited differential MATscores [ 7, 21] between NSphs, which indicate differential methylation status, and obtained a total of 1,403 NSph-T-DMRs consisting of 380 E11Hypo-T-DMRs and 1,023 E14Hypo-T-DMRs E14Hypo-T-DMRs E14Hypo-T-DMRsthylated, respectively, in E14.5NSph compared to E11.5NSph.
Among the false positives from the primary screen were 23 mutants that were also false negatives in the primary screen in the sense that they consistently exhibited altered fluorescence induction in the secondary screen that was directionally opposite to that observed in the primary screen.
The exhibits offer touch screens that can display three different explanations, the appropriate level sensed from a coded card provided each visitor.
In smaller rooms nearby, unpaid volunteer "operators" who exhibit no special powers or gifts for ESP sit by a variety of small machines -- a tabletop toy robot, a spurting water fountain and a computer screen that displays a flickering line.
