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AA carried out the genomic phenotypic screen, secondary validation screen, wrote the manuscript.
For all three analyses (primary screen, secondary screen and clustering analysis), hits were selected if their P-values were <0.05.
The difference of z-score distributions of the positive control (CD81) and the negative controls is shown in Figure 2. The separation of distributions shows CD81 as a significant down regulator in all three approaches (primary screen, secondary screen and clustering analysis method).
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In a five-step approach, including pre-screen, primary filtering of inhibitors, re-screen, secondary filtering of inhibitors and graphical inspection and final selection, CAVS leads to selection of specific STAT inhibitory compounds.
Based on (necessarily crude) estimates, age-adjusted mortality rates from cancer in year 2000 had been reduced by approximately 13% due to primary prevention and an additional 6% due to the combined effect of early diagnosis and screening (secondary prevention).
Since no extract showed macrofilaricidal activity in the primary screens, the secondary screen was limited to the mfs.
From the one hundred and six pool hits that were identified in the first round of screening, the secondary screening procedure was performed on twenty.
To get around this fact, firing up the camera will switch screens, making the secondary screen the primary.
XZ carried out the genomic phenotypic screen and secondary validation screen.
This depended on where CTC was used in the screening pathway either primary screening or secondary follow-up test.
The yeast strains screened by the secondary screening were used.
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CEO of Professional Science Editing for Scientists @ prosciediting.com