There's on-screen proof of that here, in the numerous Chandlers Mr. Jones persuaded to sit for interviews about their more charismatic fathers, grandfathers and ex-husbands.
Hands-on "screen": A proof-of-concept system allows smart phones to use virtually any surface as a touch-based interactive display.
Results obtained by screening two proof-of-concept genes are highly promising and confirms that the population is well mutagenized.
This initial screening constitutes proof-of-concept in relation to bloodstream infections and, although this is not a full validation of the oCelloScope system, the results are compared to commercially available systems.
Print the confirmation screen or proof of purchase you receive upon completing the transaction, and keep this in a safe place until the item you paid for arrives.
They design a 96-well plate in vivo screening platform for large-scale chemical screening and, in a proof-of-principle pilot screen of 2000 compounds, identify the glutamine analogue acivicin (a chemical with activity against human tumour cells) as a potent and specific inhibitor of Drosophila tumour formation.
To demonstrate the utility of the screening platform, we undertook a proof-of-principle pilot screen with the MicroSource Discovery Systems Spectrum Collection.
Indeed, while the use of cells lacking functional caspase-8 may seem redundant, they are included in the primary screen here due to the "proof-of-concept" nature of the initial screen and should allow for more rigorous identification of any anomalies.
Thus, the pilot screens provide a strong proof-of-principle that this strategy can be used to identify bona fide regulators of endosome-to-Golgi retrieval and candidate genes for further testing.
In response to specific reviewer concerns about the description of the screen (below), we have removed the proof-of-principle details of the screen from Figure 2 (to a child figure and legend for those that would like to see this part of the screen) and have streamlined the text accordingly.
In keeping with a small molecule pharmacological approach, we describe here a novel screening strategy optimized for the detection of caspase-8 pathway-specific TRAIL sensitizers, and demonstrate its usefulness by a proof-of-concept screen.
