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Lau et al. applied a genome-wide screen of DNA methylation changes using NB primary tumors [ 26].
We previously reported a genome-wide screen of DNA methylation differences among T2D cases and controls in the Ashkenazi Jew (AsJ) population.
We performed a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 platform on bulk tissue samples from the superior temporal gyrus of patients with Alzheimer's disease and non-demented controls.
Furthermore, a small case control study performed a genome-wide screen of DNA methylation patterns and identified 182 hypermethylated genes in peripheral lymphocyte DNA in 8 adults with arsenic-related skin lesions compared with 8 adults without arsenic-related skin lesions (Smeester et al. 2011).
In the present study, we have used the Illumina Infinium HumanMethylation450 array platform to conduct a genome-wide screen of DNA methylation in the superior temporal gyrus (STG) of 34 patients with AD and 34 controls, a brain region recently demonstrated to be a site of significant AD-associated gene dysregulation [ 44].
The screening of a TILLING population includes three fundamental steps: an initial screen of DNA pools to identify those that contain mutant individuals; a second screen to identify the individual within each pool that contains a putative mutation; and lastly, confirmation of the individual mutations by sequencing of the PCR products.
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In here, we adopted a non-targeted approach based on genome-wide screen of DNA-methylation changes.
Therefore, our method is a good solution for automatic screening of DNA data, especially for large DNA sequencing facilities.
It means we can use SVM for automatic quality screening of DNA chromatograms.
Screening of DNA polymorphisms in the Gn1a gene using WGS data.
We devised a new method to fulfill the quality screening of DNA chromatograms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com