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As an example, an RNAi screen conducted by Berns et al. showed that knockdown of PTEN decreased sensitivity to trastuzumab in BT-474 breast cancer cells [68].
In a separate two hybrid screen conducted using fragments of mouse TTP (mTTP) as baits, we did not identify CIN85 as an mTTP interactor (data not shown).
The preliminary screen conducted in HeLa cells was based on the assumption that silencing of a critical E3 will increase the toxicity of a Top2-directed drug.
In addition, a standardized receptor binding screen conducted with LM11A-31 (Cerep panel, Table S1) failed to detect binding of p75NTR ligands to other receptors.
The 150 gene screen conducted here is too small to extrapolate to an entire genome proper, but the core observations that some phenotypes are only detectable after the use of non-visible assays suggests that current 2000 gene numbers[14] are likely underestimates.
In the prevalence screen conducted in this study, the deregulated expression patterns detected in ∼50 ccRCC patients for five of the miRNAs further supported the finding that the miRNA genes located on Xq27.3 were expressed at substantially lower levels in at least 76.7% of primary ccRCCs compared to patient-matched normal adjacent controls.
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Small molecule screens conducted with living zebrafish have become a commonly practiced technique for small molecule discovery.
OBJECTIVE: The purpose of this study was to identify the factors that affect the quality of cytologic cervical cancer screening conducted in public sector clinics in Sonora, Mexico.
Although a large number of small RNAs (sRNAs) have been discovered, it is very likely that the screens conducted so far have not reached saturation.
Here the design of the lifestyle-intervention study is described and results are presented from the preliminary population screening, conducted between March 1999 and June 2000.
The NLST is the largest trial of lung CT screening conducted to date.
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