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Most mutations identified in this screen caused distinct abnormalities in hemocyte differentiation, but none resulted in complete loss or enlargement of the MZ, suggesting that early stages of hematopoiesis were least affected.
This apparently low hit rate of 0.04% highlights the selectivity of the screen for a differentiation-specific response; a far higher number of compounds (37% in the primary screen) caused trypanocidal or trypanostatic growth effects (as measured by alamarBlue assay), probably through multiple specific and nonspecific cellular mechanisms.
Although it appears that the compounds identified in the present pilot screen caused p27 upregulation as a secondary consequence of cell cycle delay, using nuclear p27 accumulation as a screening endpoint readily enabled the identification of cell permeable compounds with antiproliferative activity.
Similar(57)
But a 3-D object flying off the screen causes sensory conflict.
Perhaps the "spasmy thing" at the premiere came on during one of these blasts of self-awareness: the sight of herself on the big screen causing optic revolt.
The front of the screen is sealed in a translucent coating to prevent damage, but water has seeped in from the windows in the screen, causing some damage and technical problems, including arrant flashes.
After the meal she headed up two flights of stairs to the small attic room that is her office, home to an aging computer whose cloudy screen causes her consternation.
Some of these games will resize your screen, causing your icons to move around.
In a movie theater, it's the opposite: Stereo content that is placed behind the screen causes more discomfort than scenes that jump out at you.
In fact, the touch-screen interface makes the experience even more intuitive than the original – tapping on the screen causes the app to zoom in on the highlighted photo, shifting the viewer's position in the 3D scene.
Apparently the lithium ion battery behind the Zune's display is swelling from overheating and putting a great deal pressure on the screen, causing it to crack or break.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com