We aimed to identify actionable easy-to-screen alterations that would allow better diagnostics and/or treatment of this deadly disease.
Therefore, it would be advantageous to screen for alterations in visual function at a pre-clinical stage.
Although global array-based approaches can provide high resolution data on CNVs in individuals, these methods are limited by low throughput, high cost, and a long turnaround time, and there remains a need for simple, cost-efficient methods to screen chromosomal alterations across larger populations.
Publicly available array CGH datasets were used to screen for alterations at 11q13.4 to 11q14.1 in breast tumors.
The 10 K single nucleotide polymorphism (SNP) array (GeneChip Mapping 10 K array, Affymetrix) offers a high-resolution genomic approach to screen chromosomal alterations systematically.
K6001 offered the possibility to screen for alterations replicative aging via the generation of growth curves in galactose- and glucose, an alternative to time-consuming micromanipulation experiments [ 16].
12 The symptoms in the screen included alterations in cognition, behaviour, motor or sensory function, balance or coordination and the presence of pain including headache.
PCR amplification and direct DNA sequencing were performed to screen for alterations in the TPO gene using genomic DNA extracted from peripheral venous blood.
To achieve this, it will be increasingly useful to establish high-throughput methods to effectively screen for alterations in cell numbers, connectivity, and function with cell type resolution [ 134].
We found the use of RHR to screen for alterations in glucose and triglycerides interesting but, according to the data presented, we believe that there is no evidence for this.
