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Appendix 1. a) Areas of functional ability evaluated by the SMAF; b) Illustration of scoring template for an item on the SMAF.
In Fig. 2, the sequence alignment between the ERev and the best scoring template is shown along with the secondary structures obtained from the model, template structure, and that predicted using Prof. The secondary structure obtained from the model agrees well with the predicted one.
24 The component physical and mental scores were generated from the SF12 scoring template.
The answers are then assessed using a standard scoring template with points awarded for key components of each answer.
SF12 scores were calculated using the scoring template 36 and reported as physical and mental component scores (PCS and MCS respectively).
HADO homology modelling (37% aa coverage) was generated based on the highest scoring template (PDB code IU70, 98% confidence) corresponding to the magnesium-dependent phosphatase 1.
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The online survey and Excel scoring templates to analyze survey results can be found at: http://CLASS.colorado.edu.edu
Raw score scoring templates and computer scoring programs written for use with both SAS and SPSS statistical software packages are available for all FACIT measures.
In this case our algorithm reranked the top 50 templates based on the CM-score and identified as top scored template the actual best one (PDB ID: 1YY9).
All best scoring templates for the α1 domain were structures of HMG proteins.
All CLASS-Bio statements are listed in Supplemental Material A. This format typically allows respondents to complete the instrument in less than 10 min. Likewise, scoring by instructors is straightforward with the aid of Excel scoring templates.
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