We profile 554 essential C. elegans genes by imaging gonad architecture and scoring 94 phenotypic features.
All of the hematoxylin and eosin-stained liver samples were assessed by a single pathologist at Pfizer for inflammatory activity and changes in tissue architecture using scoring systems adapted from the Knodell system for inflammation [ 19] and the METAVIR scoring system for fibrosis [ 20].
The sum of scores for inflammatory cell infiltration (score, 0 4), goblet cell depletion or decreased mucus accumulation (score, 0 4), mucosa thickening (score, 0 4), destruction of architecture (score, 0 or 3 4) and loss of crypts (score, 0 or 3 4) was calculated (maximum 20).
Petrushka (the original 1911 version) is short on crazed energy and urban hubbub, but instead we get chamber-like clarity and a really crisp sense of the score's architecture.
A slightly modified form of the excerpt above was added to the relevant section of main text (subsection "A Single, Best-Scoring Subunit Architecture").
It would therefore be good to clarify these aspects to the reader and somehow down tune the general statement (notably in the Abstract, in the subsection "A Single, Best-Scoring Subunit Architecture", and in the Discussion).
The term "residue-level resolution" indeed applies only to cross-linked residues, and we have modified the text to clarify this point in the Abstract, in the subsection "A Single, Best-Scoring Subunit Architecture", and in the Discussion.
The residue-level and overall precision of the tail module subunits are reported in Figure 2 figure supplement 5A and B. To clarify these points in the manuscript we have added text to the Results section (subsection "A Single, Best-Scoring Subunit Architecture").
Sleep was scored visually for sleep architecture and CAP analysis using standard criteria.
