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The company's music director, James Levine, leads the orchestra in a gripping performance of the score — tender in its lyricism, mighty in its strength, and heartbreaking at its conclusion; Alexey Markov takes over the role of Anckarström from Dmitri Hvorostovsky.
Both tocilizumab and TNF-α inhibitor treatments also resulted in significant reductions in DAS28, Visual Analogue Scale score, tender joint count and rheumatoid factor values at 16 weeks.
Similarly, for the group in which there were changes in DECT urate volume above the SDC, the change in DECT urate score correlated with changes in the frequency of gout flares (r = 0.41, P = 0.037), but not with changes in subcutaneous tophus count, C-reactive protein, HAQ-II score, tender joint count or swollen joint count (r < 0.29, P > 0.15 for all).
There was no difference between AM and non-AM groups in terms of DAS with respect to inflammatory markers (ESR and CRP), clinical evidence of joint inflammation (pain score, tender and swollen joints counts), joint function (HAQ score and PF-SF-36) or indicators of the severity of skin and nail disease (PASI and nail severity score) (Table 2).
However, the change in DECT urate volume did not correlate with changes in other clinical features of gout, such as subcutaneous tophus count, C-reactive protein, HAQ-II score, tender joint count or swollen joint count (r < 0.20, P > 0.09 for all).
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The Wilcoxon signed rank test was used to assess the statistical significance of changes in the subjective efficacy measures (VAS scores), tender points, tender joints, ESR, CRP, B cells, T cells, and Igs, compared with their baseline values.
Initially social value was given a minimum of 10% of the overall normalised weighting when scoring tenders, but that was increased in November to a minimum of 20% of the overall weighting.
Further preliminary studies may consider including both pain score and tender joint count as the main outcome assessment.
RA disease activity was assessed using the Disease Activity Score 28 tender and swollen joint count (DAS28).
Symptom severity score (tiredness, tender points index and Fibromyalgia Impact Questionnaire) were negatively correlated with Bmax and with Vmax, and positively correlated with Km.
In the RA group, sCTLA-4 levels were correlated with swollen joint count (r = -0.25, P = 0.04) but not with laboratory parameters exploring inflammation (ESR and CRP), HAQ score, and tender joint score (all P > 0.05).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com