The second approach is to use different scores tailored to different diseases (for example, a burn score for a burn patient) that all produce a standard measure which can be compared.
Whereas the original LocARNA score is tailored for comparing single sequences or constructing multiple alignments (there used in a sum-of-pairs score), log-odd based scores, which are similarly utilized by Infernal[ 13], are more appropriate for scanning applications.
Note that the classification of risk groups based on the risk score was tailored for the priority of invitation with efficiency and not for HCC screening.
In the discovery mode, a profile HMM is computed (hmmbuild program of HMMER package 3.0) for each reference sequence (of individual BCL-2 homologs or BH3-only proteins) from a multiple alignment of their closest homologous sequences extracted after a BLAST search against UniProtKB with a score threshold tailored for each reference sequence.
MPO Explorer introduces unique methods that guide the development and validation of multi-parameter scoring profiles, tailored to a discovery project's specific objectives.
In future work, we will investigate how to design a scoring function tailored to a specific data utility requirement.
Our CVLS approach to understand the interaction of D6 with HCII utilized a variation of the dual-filter docking and scoring strategy tailored for the study of GAG−protein interactions.
The last edition of the game's oldest rivalry was a match of high intensity, if not high scoring, tailor-made for defenders.
There was no score; Mr. Reich had tailored the parts specifically to the capabilities of his players.
Having grown up hearing Handel, for example, in the fleshed-out re-orchestrations that were common in the 1930s, he made a point of seeking out the original scores and tailoring his own performances to contours that Handel would have found more familiar.
