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Web extra table 5 presents the ROC, D and R statistic for each score restricted to patients from CPRD with complete recording of laboratory and risk factor data for each score.
Correlational analyses of phosphene parameters against NPIhall score restricted to patients taking cholinesterase inhibitors (phosphene threshold: τ = –0.63, P = 0.002; phosphene response rate: τ = 0.67, P = 0.001) were consistent with the overall group relationships.
Additional covariates for patients with depressive symptoms included the following health characteristics at the waiting room screen: SCL depression score, restricted activity days due to emotional health, presence or absence of pain, and whether the primary care physician was the patient's usual source of care.
16 In accordance with the inclusion criteria, MCI patients were between 50 and 80 years old, with an MMSE score ≥24, a GDS score ≤10, a WMS-R LM I score ≤13, an LM II parts A and part B score (maximum, 50) ≤8 and a CDR memory box score restricted to 0.5.
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Final full scores and scores restricted to observational parameters were computed according to evaluation strategy C. (a) Death rates are plotted as bars.
The mean final scores clearly correlated with the kinetics of death rates at the time points of evaluation with the full scoring (A_full and B_full) performing slightly better (Fig. 5a) than the scoring restricted to observational parameters (Fig. 5b).
The mean final scores at the defined monitoring time points correlated well with the course of death rates; similar as in the sepsis model full scoring performed slightly better than scoring restricted to observational parameters (Fig. 8a).
Bars show the distribution of awarded full scores (a) and scores restricted to observational parameters (b) that have been calculated based on the evaluation strategies A, B and C at the respective time points after infection (p.i.).
The graphic red lines indicate means ± SEM of awarded full scores (a) and scores restricted to observational parameters (b), that have been calculated based on the evaluation strategies A, B and C at the respective time points after infection (p.i.).
After having his scoring restricted, Headley lost patience and after scoring 11 was stumped, trying to hit Grimmett.
As a sensitivity analysis, we also calculated propensity scores restricted to the reduced cohort of patients who developed pneumonia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com