Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
Then the residues in the highest score patch are retained as the candidate epitopes.
As shown in Figure 1, the core algorithm includes five steps: dividing antigen surface into overlapped patches, constructing undirected graph on each patch, generating extreme value distribution for each mimotope sequence, aligning mimotopes on each patch and scoring patch, and determining candidate epitope residues in the highest score patch.
Similar(58)
Signed for £8m from Ipswich as a 17-year-old, Wickham variously failed to find any sort of consistency under Steve Bruce, Martin O'Neill, Di Canio, Poyet (bar one relegation-averting scoring patch in the spring of 2014) or Advocaat.
In case of mAb 17b the second high scoring patch performed better than the top scoring patch.
The second high scoring patch partially overlapped with the top scoring patch and contained seven of the eleven residues present in the mAb 17b interface.
Using default value of parameters, EpiSearch method predicted a high scoring patch centered on residue T283 (Score: 0.943).
13, 35 When the analysis was repeated after removing the terminal cysteine residues from the peptide sequences, a high scoring patch centered at T283 (Score: 0.911) was predicted.
We also observed that the residues D279, N280, A281, K282 and T283 predicted in the high scoring patch coincide with the CD4 binding site in the gp120.
The predicted residues from the highest scoring patch are shown in Figure 4B, and to a large extent correctly predicted to be part of the interface are shown in Figure 4C.
The second highest scoring patch at residue C214 was located on the other face of the HER-2, and is not part of the interface of the antibody—Her-2/neu complex.
Despite the low sequence similarity among the input peptide sequences, the residues in the highest scoring patch shared approximately 70% sequence identity with the residues in the input peptide sequences.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com