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Because a large number of GO annotations for Ae. agypti proteins are based on sequence homology to D. melanogaster, the high correlation between semantic similarity and confidence score of interacting proteins predicted from Drosophila may simply reflect their correlation in Drosophila.
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After associating our microarray gene expression data set with a protein-protein interaction network (Fig. 6), we used jActiveModules to identify and score sub-networks of interacting genes that collectively showed significant changes in expression [ 34].
(D ) For complexes in the benchmark set, inter-EC pairs with EVcomplex score ≥0.8 give predictions of interacting residue pairs between the complex subunits to varying accuracy (8 Å TP distance cutoff).
The high scores in four scoring matrices of iMatrix are often superior frequency of interacting residue pairs.
We introduced an integrated scoring system that uses a novel combination of a set of five orthogonal scoring features covering the probabilistic, evolutionary, evidence-based, spatial and functional properties of interacting domains, which can map the interacting propensity of two domains in many dimensions.
Compound-protein pairs with high scores in i) X, ii) –X, and iii) abs (X) are predicted to be candidates of interacting compound-protein pairs.
In this work we used the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) [ 101] database to obtain COGs and their respective combined scores.
The reasons for the apparent success of bootstrap in those particular cases are difficult to explain and may be a random fluke or they may indicate that the distribution of the observed score on interacting pairs is different (e.g. have a larger variance) than that of the non-interacting ones.
There are lots of ways of interacting with the BBC".
It's my way of interacting with others.
He could rely on different methods of interacting with people".
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