The summed total score of inflammatory-related abnormalities (effusion, synovial hypertrophy, and power Doppler signal) was also calculated (range from 0 9 in each joint).
To assess potential cytoprotective and/or anti-inflammatory effects of rhTM on septic shock-induced organ injury, lung sections were analyzed using a reported histological score of lung inflammatory injuries [27].
In each section, a global alteration score of each inflammatory abnormality was calculated as the sum of the areas obtained.
According to this score, the degree of inflammatory infiltration is scored from 0 to 3 where 0 = no infiltration, 1 = slight infiltration, 2 = moderate infiltration and 3 = severe infiltration.
The sum of scores for inflammatory cell infiltration (score, 0 4), goblet cell depletion or decreased mucus accumulation (score, 0 4), mucosa thickening (score, 0 4), destruction of architecture (score, 0 or 3 4) and loss of crypts (score, 0 or 3 4) was calculated (maximum 20).
To study whether CML depositions were associated with myocardial inflammation, we studied the correlation between CML intensity score and number of inflammatory cells.
To the best of the author's knowledge, the effect of DM on the relationship between MS score and levels of inflammatory markers or adipokines has not been investigated.
The data collected included demographic characteristics, length of hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, biological levels of inflammatory markers (C-reactive protein (CRP), procalcitonin (PCT), TNF-α, IL-1β and IL-6).
The beneficial effect of TLN therapy on pain/function was likely related to a combination of effects including its anti-inflammatory effect shown by a reduction in synovial effusion size, synovitis score, and level of inflammatory mediators, as well as its effect on the initiation of bone remodelling [ 12].
