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To investigate the clinical relevance of mitochondrial DNA (mtDNA) content as a viability score in human euploid embryos.
Edges upstream of STAT1 had a higher consensus score in human than in rat (P-value = 0.0004), whereas edges downstream of MYC also showed a higher consensus score in human (P-value = 0.0287).
The intronic putative donor site located in intron 41 has a higher splicing score in human (0.90) and Pan troglodyte (0.90), while no corresponding sequence could be identified in other species analyzed.
From all the proteins measured, RPS6KA1 had a significantly higher consensus score in human (P-value = 0.0161) and WNK1 had a significantly higher consensus score in rat (P-value = 0.0498).
The titles of Table 2 and Table 3 should be as follows: Table 2 Effect of fixation conditions on HER2 immunohistochemistry (IHC) score in human gastric cancer xenografted tumors Table 3 Effect of fixation conditions on the detailed histological assessment of HER2 IHC staining in human gastric cancer xenografted tumors In addition, there is an error in Table 5.
A typical workflow looks like this: given a query disease, known causal genes of diseases that are phenotypically similar to the query disease are given a prior score in human PPI network, then the prior scores are propagated and smoothed over network such that each protein gets an association score.
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In total, 473 genes were scored in human studies.
An association between higher scores in human rescreening and higher confidence in the classification models predictions suggests that model and human experts tend to make the same mistakes.
Thus, increased expression of ADM mRNA was associated with poor overall survival in ovarian cancer (Hata et al, 2000) and high Gleason's scores in human prostate cancer (Rocchi et al, 2001).
In prostate cancer, increased expression of RUNX2 was shown to activate numerous genes associated with tumour growth and invasion (e.g., VEGF and MMPs), as well as to correlate positively with Gleason scores in human prostate cancer tissue samples (Chua et al, 2009; Akech et al, 2010).
(B ) Distribution of codon pair bias scores in human coding sequences; separate labelling of the 64 codon pairs with CpG (red) or UpA (blue) across the codon junction (3 1) demonstrates their consistent under-representation based on their component nucleotide and amino acid frequencies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com