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The top 30 fingerprint features with higher weight score for active compounds are listed in Table S1 in the Supplementary Material.
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The distance from the test and training set is then cross-referenced with the probability score for activity for active compounds from WOMBAT, giving a measurement for the active prediction performance of the models.
For instance, using the default box size gives the absolute difference between the average scores for active and decoy compounds of 0.85 for experimental and 0.73 for predicted binding pockets.
Final caries experience score was determined as the sum of the scores for active decay and filled surfaces.
MRI were scored for active inflammatory lesions by two radiologists, blinded for treatment arm and MRI time point.
Wb-MRIs were scored for active inflammation according to a recently described protocol 20 using the STIR sequences.
MRI was performed at weeks 0, 24 and 48 and was scored for active inflammatory lesions in sacroiliac joints and the spine including posterior segments and peripheral enthesitis by two radiologists, blinded for treatment arm and MRI time point.
Direct social interaction test After two additional days of housing in the partitioned cages with C57BL/6J partners, mice were scored for active social, passive social and non-social behaviour in a 10 min direct social interaction test (Fig 5B).
The lower ICC scores for active extension are related to the fact that extension scores range from 0 to 3 degrees in healthy individuals and are consistent with studies testing reliability of extension and flexion using a long arm goniometer [ 32].
Wb-MRIs of 65 patients treated either with ETA (n=35) or SSZ (n=30) over 1 year were scored for active inflammation, fatty lesions, erosions and ankylosis in the 23 vertebral units (VUs) of the spine and in the sacroiliac joints (SI joints).
Along with SPADI, scores for active and passive shoulder ROM in four different directions were gathered at baseline and follow-up (as part of the clinical trial): abduction (ABD) and flexion (FLE) from neutral, and internal (INT) and external (EXT) rotation at 45° of abduction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com