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However, in small families with limited numbers of meioses, traditional LOD score analysis using STRP markers is less informative, often showing suggestive LOD scores for regions of the genome that should be excluded and missing other regions that may contain the gene.
In contrast, traditional multipoint LOD score analysis using STRP markers on diploid DNA excluded only 67.1% (LO D−2), failed to identify any shared regions (LOD>3), and generated suggestive scores (most between 0.5–1.2) for regions that were both shared and definitively excluded by haploid analysis.
We performed a polygenic score analysis using the SNPs associated with schizophrenia in the PGC study.
Dayhoff score analysis using comparisons of all mouse N1 domain versus all human N domain ClustalX aligned sequences gives an indication, at the amino acid level, of the general pattern of evolution of these domains since the rodent / primate divergence (Fig. 10).
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Polygenic score analysis uses ensembles of SNPs from a GWAS in a discovery sample, weighted by their log odds ratios to create a score across all these alleles for each individual in an independent validation sample [Dudbridge, 2013].
The z-score analysis using Nipponbare as a reference was a compelling example of the metabolite diversity among the varieties (Figure 1C).
The ability of the various CTX forms and CTX ratios to discriminate between patients with bone metastases (HC+ patients and NC+ patients) and patients without bone metastases (NC- patients) was assessed by Z-score analysis using the mean and SD of the NC- patient group (Fig. 3).
After adjustment using the propensity score analysis, use of a liver from a DCD donor was associated with an adjusted HR of 2.3 (1.3 to 4.1) for graft loss.
We also repeated the propensity score-matched analysis using conditional logistic regression analysis to control for all covariates included in the model.
Four levels of analysis using scoring methodologies of increasing complexity were used to score the accessibility of AON target sites.
We present techniques for increasing the speed of sequence analysis using scoring matrices.
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