The Scope of Skills The computational complexity of this field demands a strong foundation in mathematics, computing, and quantum physics.
Since we have shown that the method works for a target protein and a less-stable homolog, we aim to expand the scope of the study by increasing the computational efficiency of the underlying LSE minimization problem so that it can be applied to any protein with any number of homologous sequences.
Moreover, the ubiquity of GPUs and the ingenuity of the simulation community augur well for the scale and scope of future computational studies of biomolecules.
Second, it is apparent that a proportion of genes in each genome is outside the scope of computational predictions made by the GOA project, and has only literature-based GO annotations.
Because of the continuous development of more efficient algorithms harvesting ever-expanding computational resources, and the emergence of more advanced and novel theories and methodologies, the scope of computational studies has expanded significantly over the past decade, now including much larger molecular systems and far more complex molecular phenomena.
As a further step in assessing the feasibility of this method, we investigated the scope of computational predictions, since any strategy comparing literature-based annotations with computational predictions can only be effective if both are available for the comparison.
After machine vision software necessary to generate the initial raw data (which is beyond the scope of our review), computational tools are necessary to align to each other and assemble together individual Rmaps, as well as to align the assembled maps to each other (e.g., when identifying structural variants), or to genomic sequences (e.g., to validate or assist the genome assembly process).
The detailed analysis of predicted results with reference to experimental data and the results obtained for flow over a single impeller blade will be useful for extending the scope of computational fluid dynamics (CFD) based tools for engineering gas liquid stirred reactors.
This underscores the critical need for manually performed, literature-based curation to provide functional information about genes that are outside the scope of widely used computational methods.
