These significant covariate effects included time trend, baseline score, age, gender, gross appearance of tumour, scope of gastric resection and hemipancreaticosplenectomy.
The time trends of functional outcomes had to be adjusted by significant interaction effects with time, including scope of gastric resection, gross appearance of tumour, age and baseline score.
The lymph node dissection effects on the functional outcome, and Spitzer QOL Index were examined by the linear mixed models (Diggle et al, 2002), adjusting for fixed effects for each time point, treatment, baseline covariate, age, sex, marital status, scope of gastric resection and gross appearance of tumour, and with random effects for intercept and each time point.
Approximately 20% of patients with colorectal cancer present with advanced disease (Young and Rea, 2000), that is, disease which is already beyond the scope of curative resection, and a further 20 30% go on to develop advanced disease at a later date.
Scope of surgery is of special concern to surgical oncologists and radiologists because it is the most important determinant of resection quality, reconstruction and scope of adjuvant radiotherapy.
had a difference in scope and so did not inquire about timing of resection nor about differences in management based on the changes of the metastatic lesions during treatment.
Patients with PR (decrease in scope of surgery) were assigned to surgical resection without neoadjuvant RT.
A large majority of patients present with advanced disease that is beyond the scope of cure, and even after surgical resection with curative intent more than 50%% of patients will develop recurrence and/or distant metastases [ 3].
In this study, we aim to answer whether response to neoadjuvant therapies correlated wth decreased scope of surgery and decreased rate of R2 resection in locally aggressive STS.
The introduction of high-dose-rate intraoperative radiation therapy (HDR-IORT) combined with radical surgical resection has widened the scope of patients who may be offered surgery [ 9], however, this form of radiation delivery is not widely available.
