This is certainly consistent with the number of guidance systems that have been linked to these regulators [35], [92] [94] and the scope of guidance defects detected in our embryos.
While an alteration in midline guidance decisions may also account for the AEP defects, the scope of guidance errors observed in neurons leaving the CNS suggest that increasing Abl activity could also be affecting other guidance systems not directly associated with the midline.
These include determining the scope of guidance, submitting evidence, commenting on draft guidance, and checking guidance revisions prior to publication.
However, the Association of British Insurers, one of the main industry bodies, said the announcement "adds little of value on what really matters: the content and scope of the guidance".
White House spokesman Robert Gibbs released a statement on the inquiry, saying: "The president has said repeatedly that he wants to look forward, not back, and the president agrees with the attorney general that those who acted in good faith and within the scope of legal guidance should not be prosecuted".
In scope of PAT guidance, it would be advantageous to estimate and to monitor the amount of agglomerates during a coating process in real time.
This group concluded by discussing and clarifying the scope of the guidance, i.e. excipients, impurities in biologics, if the impurity is a small molecule.
The scope of the guidance documents varies with some focused on technical aspects [4, 6, 7, 8, 9, 10], whereas others include also clinical aspects (e.g. epidemiology, interventional, pathology, surgery) [7, 11].
The scope of this guidance does not cover family and social risk factors, which may in themselves be alerting features.
When applying for funding, one should highlight how the specific case is unique, and thus outside the scope of NICE guidance.
The scope of this guidance document, which was completed between July 2011 and March 2013, considered a host of domains related to PRO-AEs, including definitions and suitable taxonomies, the range of datasets that could be used, data collection mechanisms, and suitable analytical methodologies.
