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This diversity may reflect the broad scope of genes that interact with arsenic (Tables 3 and 4).
Both points of criticism are resolved in Gene Set Enrichment Analysis (GSEA) as it uses a valid sampling procedure and computes over the whole scope of genes (Subramanian et al., 2005).
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In addition, >60% of human genes are predicted to be miRNA targets (Friedman et al., 2009), suggesting the large potential of these RNAs in shaping the scope of gene expression.
To get a sense of the broad scope of gene patenting, consider this: Since 1984, the US Patent and Trademark Office has issued around 40,000 patents related to human genes, covering around 20percentt of the human genome, according to a 2005 study in Science.
As H1N1 viral titer was lower at 24 hpi than titers of other viruses (Figure 1B), the scope of gene-expression changes induced upon infection correlated, at least partially, to the viral replication efficiency of the virus-cell system used in this study.
However, the scope of gene and chromosomal amplifications has been limited in CC.
This low positive rate necessitates the urgent detection of appropriate clinical information to narrow the scope of gene testing.
Whole genome duplication circumvents these constraints and relaxes the dichotomy, resulting in an expanded functional scope of gene duplication.
It should, however, be emphasized, that the problem of nomenclature inconsistencies is not exclusive to the rat and goes well beyond the scope of gene symbols.
Although the scope of gene expression data is growing, new increasingly advanced algorithms to integrate these datasets into CBMs are also being developed [ 44].
TMA is a powerful tool to validate DNA microarrays data and extend the scope of gene expression profiling to the post-transcriptional level.
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