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The phrase "scientific problem" is correct and usable in written English.
You can use it when you want to refer to a problem that has scientific implications or requires a scientific approach to solve. For example, "Global warming is a serious scientific problem that requires urgent attention."
Dictionary
scientific problem
noun
An observation that contradicts an accepted law or theory.
Exact(58)
It was a scientific problem.
I may work on a scientific problem.
A scientific problem ought to be solved by data.
"Image analysis is a difficult scientific problem," he said.
It was seen as a product-development issue, not a scientific problem.
"No difficult scientific problem is ever solved in a single paper.
"Global warming is not a political problem – it's a scientific problem".
"An attempt by countries to act globally for a scientific problem.
Studying the brain, particularly the living brain, is a uniquely hard scientific problem.
But the effort to stop autism in its tracks with earlier interventions presents a scientific problem.
Even with the scientific problem far from resolved, research like this inevitably turns us into narcissists.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com