In such circumstances scientific "estimates" do not deserve to be called any more than the wildest of wild guesses.
But many experts on the circumstances — scientific, diplomatic and economic — surrounding the 1987 treaty signing say that while some things are similar now, like the looming environmental risks revealed by evolving science, almost everything else is very different.
Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail.
The principles of evidence-based medicine require GPs to use their expertise to strike a balance between patients' clinical status and personal circumstances, scientific evidence and the patients' preferences [ 22].
In his hands, the camera would serve to reveal with quasi-scientific objectivity the circumstances of various understudied populations.
An important role for scientific institutions in these circumstances is to act as what Harvey Brooks called 'the conscience of technology' (pdf).
What's more, I realized that I'd misjudged the show's politics: the series is much grimmer than I'd understood, less preachy and more legitimately nihilistic about the circumstances surrounding scientific and social progress.
This would require regular re-appraisals, probably every five years, of countries' emissions targets, with a view to ratcheting them upwards to meet scientific advice, as countries' circumstances permit.
In other words, unexpected and undesirable circumstances in scientific endeavours do not only limit and constrain us, one can still choose to go with their flows circumstances can always be creatively used to re-make possibilities and tap new potentialities to our advantage.
"While the Congresses that drafted [the Clean Air Act] might not have appreciated the possibility that burning fossil fuels could lead to global warming," Stevens wrote, "they did understand that without regulatory flexibility, changing circumstances and scientific developments would soon render the Clean Air Act obsolete".
