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I regret very much that the science, substance, and heart that we put into the project will never be seen.
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About the transcendentals, Aristotle made metaphysics the science of substance.
Suffice it to say that Aristotle conceives of this wisdom as a science of substance that is, or is a part of, a science of being qua being (for further information about this argument, see the entry Aristotle's Metaphysics, especially Sections 1 and 3).
In the case of substances, however, the real and nominal essences are always different, and so there is no possible human science of substances (IV.vi.12 16).
Pseudoscience is the form of science without the substance.
"Great Waters" frequently relies on science for its substance, but Cramer's work lacks the scientific attitudes of objectivity, skepticism or the impulse to investigate conundrums.
A cure for the ailing church "would require a much deeper ecclesial comprehension than the present leadership currently exhibit … There seems to be no sagacity, serious science or spiritual substance to the curatives being offered".
In many disciplines, particularly in chemistry, physics, and materials science, chemical compounds (substances) play a major role.
Fun, to them, often means cheap thrills and even cheaper science, containing as much substance as a fistful of cotton candy.
The scientist's job is to "protect the substance of science from those with nefarious motives".
This is a standard modus operandi of pseudoscience: it adopts the external trappings of science, but without the substance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com