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The potential benefits of amifostine may have been obscured by inability to provide full amifostine doses due to toxicity associated with infusion, scheduling of doses, and inadequate follow-up to monitor severity of esophagitis over time.
Scheduling of doses was done at the point of prescribing.
The scheduling of doses and drug administration was based on previously reported studies [ 36, 37] and on pilot studies in our models.
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It is important to note that the form of the additivity model does not include information about scheduling of dosing, because single-chemical data were available only with the SLT protocol.
The 60-patient two-month clinical trial of the medication, lercanidipine, was conducted in response to a 2002 Food and Drug Administration request for more data on the effectiveness of a proposed schedule of doses, Forest said.
The adolescent phase IIb/III study (V72P10; NCT00661713) enrolled 1,631 subjects in Chile from June 2008 to determine the number and schedule of doses necessary to establish immunogenicity, and the tolerability of those doses, as described by Santolaya et al. [ 29].
Although oral etoposide potentially offers a superior schedule of dosing (Slevin et al, 1989), this has been questioned (Girling, 1996).
The aim is to study the effectiveness of dexamethasone to prevent the occurrence of a pain flare after radiotherapy for painful bone metastases and to define the optimal schedule of dosing.
In the present study we examined neurobehavioral effects of TCVs using both an accelerated vaccine primate schedule and the recommended pediatric schedule, neither of which appeared to affect neurobehavioral outcomes, thus suggesting that the toxicokinetics of EtHg in infant primates is not a limiting factor when using an accelerated schedule of dosing.
Although the biweekly dosing schedule used in this study demonstrated apparent activity, the serum levels of antibody measured here appear to be less than those in studies of NHL, where a weekly schedule of dose administrations has shown antitumor activity [ 42- 44].
Rouhiainen and Tade (2003) developed a single-objective GA to optimize scheduling of chlorine dosing in DWN.
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