Sentence examples for scheduling effects from inspiring English sources
In this trial based on our earlier work (O'Reilly et al, 2003), everolimus was administered weekly immediately before paclitaxel infusion to avoid or minimise scheduling effects.
Since mTOR inhibitors alone can suppress AR-dependent cyclin D1 accumulation and cell cycle progression, it was hypothesized that these cytostatic effects underlie the scheduling effects of mTOR inhibitors.
To assess how the drug scheduling effects might be explained, we examined HCT-116 and HKE-3 cells for possible differences in cell cycle, DNA damage or ROS levels in response to staged treatments with the same low doses of topotecan and bortezomib.
Because changes in bout length are primarily related to schedule effects [ 18, 20, 39, 42], it is likely that the persistent length of SHR bouts reflects a low sensitivity to changes in reinforcement schedule.
The schedule effect is observed first in simulated time histories of the infectious population.
In vivo combinations of everolimus with paclitaxel showed additive and synergistic effects in tumour models but with a schedule effect, in that administration of everolimus 1 day before or after paclitaxel reduced anti-tumour activity (O'Reilly et al, 2003).
As a result, the schedule effect on efficacy or safety could not be separated out, when dose level per administration or average dose per week is included in the model.
Future work to assess area under the concentration time curve response relationship may allow better quantitative comparison of schedule effect on efficacy and safety and extrapolation across dosing regimens.
The dose-scheduling effects of combining selumetinib and docetaxel lead us to investigate the sequence dependency of selumetinib combined with another mitotic targeting agent, the Aurora B kinase inhibitor, barasertib (AZD1152) (16).
Each objective contributes to scheduling comprehensive effects.
In this scheduling, the effects of reliability and costs are adjusted at 0.7 and 0.3, respectively.
