Alternative schedules are needed to provide greater immunogenicity in adults who fail to respond to the standard hepatitis B (HB) vaccine regimen.
However, further studies on the difference in long-term adverse effects between different treatment schedules are needed, especially concerning adverse effects on, e.g., the kidneys.
Further experiments employing a wider range of timing schedules are needed to investigate this possibility.
However, rational strategies for developing new metronomic chemotherapy protocols and schedules are needed in order to improve the knowledge and application of this therapeutic regimen.
Recent studies [ 3, 5- 7, 22, 23] have found that strict treatment schedules are needed to obtain the optimal effect of ranibizumab treatment over the long term.
Overall, this appears to support the view that dosages higher than needed for the treatment of bacteraemia and/or improved administration schedules are needed to treat deep-seated infections (such as pneumonia and intra-abdominal infections), with hydrophilic antimicrobials to ensure optimal pharmacodynamic exposure at the infection site [ 5, 13, 14].
Therefore a new schedule is needed considering both original objective and the deviation from the initial schedule.
Therefore, in this paper we consider an integrated lot-streaming flow shop scheduling problem in which lot-splitting and job scheduling are needed to be optimized simultaneously.
For this purpose, hierarchical scheduling is needed for upstream bandwidth allocation, with high-level scheduling for inter-optical network unit (ONU) allocation and low-level scheduling for intra-ONU distribution.
Although engineering approach estimates energy use with greater accuracy, it falls short in the overall complexity of model building and simulation in which detailed data that represent the building geometry, systems, configurations, and occupant schedule is needed.
