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Patients who received sunitinib by the two different treatment schedules (Schedule 4/2 and CDD) were analyzed separately (data not shown).
Patients were treated with temozolomide on one of the following two protracted administration schedules: Schedule A. Temozolomide administered daily for 7 days repeated every 2 weeks.
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Flexible schedules: Schedules that Work Act (S. 1772).
4. Schedule, Schedule, Schedule!
First, patients received sunitinib on a 4-weeks-on-2-weeks-off schedule (Schedule 4/2) plus gemcitabine on days 1, 8, 22, and 29.
Second, patients received sunitinib on a 2-weeks-on-1-week-off schedule (Schedule 2/1) plus gemcitabine on days 1 and 8.
Michaelson et al. assessed two different schedules of the combination therapies of (a) sunitinib on a 4-weeks-on-2-weeks-off schedule (Schedule 4/2) plus gemcitabine on days 1, 8, 22 and 29, and (b) sunitinib on a 2-weeks-on-1-week-off schedule (Schedule 2/1) plus gemcitabine on days 1 and 8 [ 14].
Animals treated with the standard dose schedule (schedule A) received intraperitoneal temozolomide at a dose of 200 mg m−2 for 5 days, and those treated with the dose-intense schedule (schedule B) received temozolomide at a dose of 100 mg m−2 for 21 days.
Yoshino et al recently reported that sunitinib plus mFOLFOX6 had acceptable tolerability in treatment-naïve colorectal cancer, but that a 2-week on/2-week off schedule (schedule 2/2) was generally more manageable than schedule 4/2.
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