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However, further studies on the difference in long-term adverse effects between different treatment schedules are needed, especially concerning adverse effects on, e.g., the kidneys.
Alternative schedules are needed to provide greater immunogenicity in adults who fail to respond to the standard hepatitis B (HB) vaccine regimen.
Further experiments employing a wider range of timing schedules are needed to investigate this possibility.
Recent studies [ 3, 5- 7, 22, 23] have found that strict treatment schedules are needed to obtain the optimal effect of ranibizumab treatment over the long term.
However, rational strategies for developing new metronomic chemotherapy protocols and schedules are needed in order to improve the knowledge and application of this therapeutic regimen.
Overall, this appears to support the view that dosages higher than needed for the treatment of bacteraemia and/or improved administration schedules are needed to treat deep-seated infections (such as pneumonia and intra-abdominal infections), with hydrophilic antimicrobials to ensure optimal pharmacodynamic exposure at the infection site [ 5, 13, 14].
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In contrast, in immunocompromised animals the 50% protective dose was 15-fold lower when using continuous infusion, even if higher doses for both administration schedules were needed (1.52 mg/kg versus 24.37 mg/kg).
Therefore, in this paper we consider an integrated lot-streaming flow shop scheduling problem in which lot-splitting and job scheduling are needed to be optimized simultaneously.
In order to apply streamline numerical simulation to determine the ratio of injection production control area, geology model, fluid property and well schedule are needed to build the streamline model.
However, only few rabbits were necropsied at non-planned time points, a larger number of animals with higher infectious dose and planned optimal necropsy schedule are needed to definitively characterize the hepatic lesions associated with rabbit HEV infection in rabbits.
However, in all these studies the toxicities associated with the Topo I poison were exacerbated, indicating that improvements in either dosing or scheduling are needed.
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