Book deals are inked, interviews are scheduled, and rationales for finding someone guilty (or not) are explained.
Considering that the combination effect is schedule-dependent, the rationale would be to administer the gefitinib when chemotherapy is inducing or has induced maximum tumor damage.
Explaining his rationale for scheduling the millennium bash for the New Year's Eve just ahead, Mr. Webb said: "We're Westerners.
The rationale underlying this schedule was that VDA-treated tumours rapidly regrow from the rim of residual viable cells at the tumour periphery that shows prominent proliferative activity (Thorpe, 2004; Tozer et al, 2005).
The rationale for this schedule was that the vascular effect of the VDA would cause 'trapping' of the already present cytotoxic drug within the tumour, and, at the same time, that the possible VDA-induced impairment of PTX distribution in the tumour would be avoided (Chaplin et al, 2006).
The rationale behind this scheduling algorithm is very simple: If the throughput guarantee of user i is already fulfilled, then it is not selected in the remaining time-slots, i.e., the value of v i (t k ) is set to zero.
The rationale behind this scheduling algorithm is as follows: The value of ρ i (t k ) expresses the normalized share of the throughput guarantee that is to be fulfilled in the remaining K - k time-slots of the time-window T W. If the rate guarantee is already fulfilled, then the value of ρ i (t k ) is zero, which means that the user in question is not selected in the remaining K - k time-slots.
Furthermore, our studies have also explored the rationale for sequence scheduling when MEK inhibitors and agents targeting mitosis are combined.
These observations established the rationale for the schedule-dependency and likely antitumor activity, and formed the basis for the design of the first Phase I dose escalation study.
Here, we identify cells in G2 that are capable of escaping topoisomerase I inhibition, with major implications for the design rationale for the scheduling of topotecan anticancer therapy.
The rationale of this scheduling for 5-FU was based on our previous observations which indicated that HDFL is in general a highly effective and very safe regimen for advanced gastric cancer (Hsu et al, 1997; Yeh and Cheng, 1998).
