The effect of temporal reuse on schedule capacity is determined for schedules optimised in the unaware rate region C with transmission rights extended afterwards.
Extensive computational experiments show improved schedule capacity, quality of service, power efficiency and benefit from network coding accrued with schedules optimised in the proposed temporal reuse-aware convex rate region.
By concentrating on some of the most promising areas, further simulations with schedules optimised for the three-station configurations may provide even better insight on the optimal three-station network geometry.
Furthermore, the observation schedules are optimised to determine a set of target parameters.
Studies of these newer PCV are required in special risk populations to assess both their safety and immunogenicity and help determine the best schedule to optimise IPD protection.
Estimation of tumour proliferation may allow the design of individualised radiotherapy schedules to optimise response.
As previously described, the determination of MTD for MK-2206 and MK-0752 as single agents has been challenging (Yap et al, 2011; Krop et al, 2012), requiring the evaluation of different treatment schedules to optimise tolerability.
Our findings may have been influenced by several factors: chemotherapy administered at relatively low doses while following a frequent metronomic schedule may have optimised the antiangiogenic effect of cytotoxic agents, providing better results than an intensified weekly schedule (Kurzen et al, 2003).
This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.
For most of these problems, the main concern is to find the best way to prioritise or schedule jobs to optimise some objectives such as makespan, mean flowtime, maximum flowtime, mean tardiness, and total weighted tardiness.
