We used a case-cohort study design to examine the relation between history of benzodiazepine prescription, dose, type, and schedule and risk of death from drug overdose over a six year period among a nationwide sample of patients who received treatment with opioid analgesics in the Veterans Health Administration VHAA).
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Objective To study the association between benzodiazepine prescribing patterns including dose, type, and dosing schedule and the risk of death from drug overdose among US veterans receiving opioid analgesics.
Participants completed a clinical assessment that included a self-report measure of desire for hastened death in the medically ill (Schedule of Attitudes toward Hastened Death), three measures of cognitive functioning designed to screen for cognitive impairment (Dementia Rating Scale, Mini-Mental State Exam, HIV Dementia Scale), and other measures of physical and psychological functioning.
The period of risk ended at either the 24 month follow-up visit, the midpoint of the last visit seen (if earlier than month 24) and the following scheduled visit date, date of death or date of TB diagnosis (defined as the start date for treatment) whichever came first.
A random sample of 128 patients completed the Schedule of Attitudes toward Hastened Death (SAHD) at two time points approximately 2 4 weeks apart participated.
An autopsy is scheduled to determine the cause of death.
An autopsy to determine the cause of death was scheduled for today.
A spokeswoman for the medical examiner's office said an autopsy to determine the cause of death was scheduled for today.
Benzodiazepine dosing schedule was not associated with risk of death from drug overdose.
The present study, powered to rule out a 0.67 hazard ratio of death with the weekly schedule, suggests survival be very similar with the two compared schedules (HR of death 1.04), although, of course, interpretation of data in terms of equivalence (Jones et al, 1996) is not allowed.
