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These data suggest that the optimal schedule for combining AZD1152 and oxaliplatin within the time frame chosen for the experiments is concurrent treatment.
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That is, sequential treatment using 5-FU followed by sorafenib seems to be the optimal schedule for combined administration of the two agents.
That is to say, sequential treatment of 5-FU followed by sorafenib seems to be the optimal schedule for combined administration of the two agents.
Based on this premise, a phase I study was carried out to determine the optimal dose and administration schedule for combined UFT+GEM therapy in patients with advanced non-small cell lung cancer.
However, given the synergistic interaction between 24 h pemetrexed and 1 h gemcitabine, the 24 h MTA → 1 h dFdC → RT turned out to be the preferred schedule for combined administration with radiotherapy in our preclinical model system.
A phase I study was carried out to determine the optimal dose and administration schedule for combined UFT plus gemcitabine therapy in patients with non-small cell lung cancer.
In this prospective pilot study, patients with stage IV adenocarcinoma of the lung who were scheduled for combined carboplatin-paclitaxel-bevacizumab treatment were enrolled.
i Scheduled for combined surgery, for example, cataract and trabeculectomy.
Nevertheless, an improved schedule for the combined Doc and G-CSF therapy is yet to be determined.
What will be the most optimal schedule for radiotherapy combined with WEE1 inhibition in OS remains to be tested in vivo.
Hence, there is a biological rationale for combining TDP1 inhibitors with radiotherapy (El-Khamisy et al, 2007), either alone or in the context of chemoradiation schedules.
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