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However, some schedule dependency has been noted.
The schedule dependency of IHL-305 was also examined.
However, strong evidences of schedule dependency were observed.
There is little evidence of schedule dependency and simultaneous administration should be feasible.
All the data suggested a dose and/or schedule dependency that needed to be further explored.
Furthermore, pharmacokinetics were evaluated for arms A, B and C, and a possible schedule dependency for irinotecan was explored.
Similar(42)
Mikkelsen, T. et al. Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency.
Schwartsmann G , PetersGJ, Laurensse E, de Waal FC, Loonen AH, Leyva A, et al. DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects.
The same time intervals as in a previous study investigating the schedule-dependency of gemcitabine treatment combined with radiation were included [ 34].
These observations established the rationale for the schedule-dependency and likely antitumor activity, and formed the basis for the design of the first Phase I dose escalation study.
Finally, we examined the schedule-dependency of IHL-305 on the therapeutic effect, since the efficacy of the test compound against the aggressive progression of peritoneal metastasis depends on the administration schedule [ 26].
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