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The schedule dependence is critical because of the relatively short half-life of MK-8776 in patients' plasma [ 8].
However, to characterize schedule dependence, there is a need to use the drug concentration time profile to drive the response.
The Canadian National Cancer Institute conducted a randomised phase II trial to investigate the schedule dependence of topotecan (Hoskins et al, 1998).
Here, we address the importance of appropriate drug scheduling when gemcitabine is combined with the Chk1 inhibitor MK-8776, and the mechanisms involved in the schedule dependence.
The evidence shown suggests that the observed schedule dependence can be attributed to the impact of mTOR inhibitors on cell cycle progression.
The in vitro studies described here demonstrate the schedule dependence underlying the interaction between topoisomerase I and II inhibitors (SN-38 was used for in vitro experiments as it is also a topoisomerase I inhibitor).
Similar(52)
A D-step memory in the service-vacation process represents the scheduling dependence on D previous decisions and can be used to account for an increased degree of fairness between users.
Our CPN based scheme addresses two key issues on task scheduling problems, dependence detecting and task dispatching.
Concepts such as float can be read from a linear schedule (LS) and dependences are represented in the form of buffers which can be measured in the progress dimension as well as the time dimension.
The BN incorporates a direct causal dependence of schedule performance and mitigation actions to the consequences of schedule performance.
11 This is because of commonly identified schedule- and sequence-dependence of pharmacological effects of anticancer combination treatments.
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