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A preliminary attempt to investigate an hourly dose schedule demonstrated a modest anti-tumour effect accompanied by enhanced toxicity.
The BMF schedule demonstrated superior progression-free survival in first-line MBC (8.2 vs 6.7 months for CMF; Von Minckwitz et al, 2005).
Animals in both groups received similar dosing and timing of TCVs; thus, it appears that animals receiving TCVs on the accelerated schedule demonstrated improved performance during reversal testing.
Pharmacodynamic studies included in the daily continuous dosing schedule demonstrated significant inhibition of epithelial growth factor receptor (EGFR) phosphorylation and downstream members of MAPK pathway by immunohistochemistry at early, as well as multiple dose levels [3].
A previous Phase I study of entinostat using a 7- or 14-day schedule demonstrated rapid drug absorption with a Tmax reached within 1 h and a large degree of variability in clearance (24 68%) and Cmax (106 285% Gore et al, 2008).
Experiments to determine immunogen concentration and dosing schedule demonstrated that 1 or 2 μg of Ab coupled with peptide gave an equivalent response (data not shown) but three vaccinations 2 weeks apart induced the strongest and most consistent response with four of five mice responding (Fig. 1B).
Similar(54)
As their expedited schedule demonstrates, all the justices are aware of the political calendar.
The schedule demonstrates the school's priorities.
These data indicate that the 3-h infusion schedule demonstrates promising activity and supports utilising this schedule in future studies.
In fact, paclitaxel (and its novel formulations) both at MTD and at low dose schedules demonstrated significant antiangiogenic activity.
Both vaccination schedules demonstrated an acceptable safety profile when administered to healthy Indian children at 9 and 15 months of age.
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